Associations Between Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor and Disease Severity Among Women With Preterm Eclampsia and Preeclampsia

R Hastie; L Bergman; SP Walker; T Kaitu’u-Lino; NJ Hannan; F Brownfoot; S Schell; A Harper; P Cannon; CA Cluver; S Tong

Journal article

Associations Between Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor and Disease Severity Among Women With Preterm Eclampsia and Preeclampsia

R Hastie, L Bergman, SP Walker, T Kaitu’u-Lino, NJ Hannan, F Brownfoot, S Schell, A Harper, P Cannon, CA Cluver, S Tong

Journal of the American Heart Association | WILEY | Published : 2022

DOI: 10.1161/JAHA.121.024395

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Abstract

BACKGROUND: The angiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) are postu-lated to be pathogenic disease drivers of preeclampsia. If true, then circulating levels should become more deranged with increasing disease severity. METHODS AND RESULTS: We investigated the association between circulating sFlt-1 and PlGF levels and severe adverse maternal outcomes among 348 women with preeclampsia. Compared with 125 women with preeclampsia without severe features, 25 women with preeclampsia and any of hemolysis, elevated liver enzymes, low platelet count syndrome, disseminated intravascular coagulation, or severe renal involvement had sFlt-1 levels th..

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University of Melbourne Researchers

Roxanne Hastie Author

Susan Walker Author

Tu'uhevaha Kaitu'u-Lino Author

Natalie Hannan Author

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Awarded by Märta Lundqvists Stiftelse

Funding Acknowledgements

This work was supported by National Health and Medical Research Council Fellowships to Drs Hastie, Tong (#1136418), Kaitu'u-Lino (#1159261), Brownfoot (#1142636), and Hannan (#1146128). Dr Bergman is supported by the Swedish Society of Medical Research. This study is supported by the Swedish Foundation of International Cooperation in Research and Higher Education, Preeclampsia Foundation, Marta Lundqvist's foundation, Ester Asberg's foundation, Jane and Dan Olsson's foundation, Center for Clinical Research Dalarna, the Swedish Society of Medicine, and the Swedish Research Council. The funders played no role in study design or analysis.